Other than the massive engine, seven-speed automatic transmission, Magic Ride Control, and RWD only drivetrain configuration, the S650 shares its features list with the S560, which includes a 12.3-inch infotainment display with navigation, satellite radio as well as Apple CarPlay and Android Auto integration, wireless phone charging and a standard Burmester 3D surround sound system with 26 speakers as well as safety gear such as a head-up display unit and route-based speed adaptation.